In spring 2013, the American College of Veterinary Internal Medicine (ACVIM) Consensus Statement on the Diagnosis of Hyperadrenocorticism will be published in the Journal of Veterinary Internal Medicine. A key to any effective diagnostic plan is the clinician’s ability to select the most appropriate patients for testing. It is especially important to recognize that due to routine screening of broad blood chemistry panels, patients are being tested for Cushing’s syndrome at a much earlier phase of the disease than 15 to 25 years ago. Caveat emptor.